I downloaded Amplitube 5 and have a PreSonus Audiobox USB. Plugged everything in and can have sound comping through to the headphones. I can see that Amplitube has input and output coming in and can use the tuner.
Problem is, the effects are never applied. I have the amp and pedals selected and powered on but the effects are not being applied to the sound. It's just guitar going straight through.