On my new audio interface Amplitube 4 sounds like it has a blanket over it. I can fix this by running it through reaper, but it still sounds no where near as good as the old Amplitube metal software. I don't have this problem with my old audio interface with it Amplitube 4 sounds much better than the older version, but with my new Audio interface Amplitube 4 isn't sounding good.
The old interace is a line 6 guitaport [ very old interface]
The new one is a Marian Seraph AD2 PCI-e audio interface.