Hello. I have this issue on both of my laptops with different Windows (10 and 11 64bit).
My Keys 49 I/O always connect to usb of my laptop and it is the main audio output device. When I switch on my laptop and Windows have been started there is no Keys 49 I/O in connected device. Each time I have to reboot my Keys I/O by switch at behind board. How to fix it?